Ubrogepant – the first of the gepants is out now

5th January 2020, Dr Chee L Khoo

Last week, we explore the updated pathophysiology of migraine and foreshadow the arrivals of the gepants and the “mabs”  As the article went to press, the FDA approved the first of the gepants, ubrogepant for the acute (immediate) treatment of migraine with or without aura (in adults. It is not indicated for the preventive treatment of migraine. The approval came following two positive Phase II randomised control trials supporting ubrogepant’s efficacy and safety. Are they really that revolutionary in their efficacy?

The ACHIEVE II trial is a Phase 3, multicentre, randomised double-blind placebo controlled, single-attack clinical trial conducted in the USA (1). The results were published in the JAMA in November 2019. 1686 participants, 18-75 years old who had at least 1 year history of migraine, whose migraine onset were before the age of 50 years were randomised to either receive placebo, 25mg ubrogepant or 50mg ubrogepant for treatment of a single migraine attack with the option of taking a second dose if required.

The primary outcomes were freedom from pain (i.e. no pain) at 2 hours and absence of other bothersome migraine associated symptoms at 2 hours. Secondary outcomes were pain relief at 2 hours, sustained pain relief between 2 to 24 hours, sustained freedom from pain between 2 to 24 hours, and absence of symptoms associated with migraine (photophobia, phonophobia, and nausea) at 2 hours.

Patients with clinically significant haematologic, endocrine, cardiovascular, cerebrovascular, pulmonary, renal, hepatic, gastrointestinal, or neurologic disease and a history of 15 or more headache days per month on average in the previous 6 months were excluded. In other words, these are a “safe” group of patients.

Results of ACHIEVE II trial

At 2 hours, 25mg ubrogepant were significantly better than placebo in achieving freedom from pain (20.7% with the 25mg ubrogepant vs 14.3% with placebo). 50mg ubrogepant was only marginally better than 25mg ubrogepant in getting rid of pain at 2 hours (21.8% with 50mg vs 20.7% with 25mg ubrogepant). Only 50mg ubrogepant got rid of bothersome symptoms of migraine at 2 hours – see Table 1.

The incidence of treatment-emergent adverse events was low and was similar between the ubrogepant groups and the placebo group. Nausea was the most commonly reported event within the first 48 (2%) and within 30 days (2%). 1 participant in the 25-mg group reported 7 serious adverse events related to a bicycle accident; none were considered treatment related. No death or discontinuations due to an adverse event were reported.

After treatment, 4 participants were found to have AST/ALT >3 times upper limit of normal. 3 were not thought to be related to treatment (other causes found) and one was in a participant in the placebo group.

A second Phase II randomised double-blind placebo-controlled trial was conducted with the study population fairly similar to the ACHIEVE II study above (2). In this study, participants were randomised to either placebo, 50mg ubrogepant or 100mg ubrogepant. The results were published in the NEJM in December 2019.

In this study, participants who had clinically significant coronary or cerebrovascular disease and abnormal liver functions tests (ALT >1.5 times normal) were excluded. Participants with moderate-to-severe cardiovascular risk factors were allowed.

Results of second trial

Both the 50mg and 100mg ubrogepant groups were significantly better than placebo in achieving freedom from pain at 2 hours. At 2 hours after the initial dose, 11.8%, 19.2% and 21.2% of participants were free of migraine pain in the placebo, 50mg ubrogepant and 100mg ubrogepant groups respectively. Absence of bothersome migraine symptoms were also significantly achieved in 27.8%, 38.6% (p=0.002) and 37.7% (p=0.002) in the placebo, 50mg ubrogepant and 100mg ubrogepant groups respectively (See Table 2).

28.7% of the placebo group needed a second dose, while 16.3% of the 50mg ubrogepant group and 15.2% of the 100mg ubrogepant required a second dose of their medications. The most common adverse events were nausea, somnolence, and dry mouth (reported in 0.4 to 4.1%); these events were more frequent in the 100-mg ubrogepant group (reported in 2.1 to 4.1%).

After treatment, 6 participants were found to have ALT/AST >3X ULN. 4 were adjudicated not be related to the treatment. The 5th was in the placebo group while the 6th were in the 100mg ubrogepant group.


Ubrogepant in the doses of 25mg to 100mg is effective in achieving freedom from pain in patients with acute migraine. 25mg ubrogepant does not achieve freedom from bothersome symptoms of migraine while 50-100mg does. Both trials were comparing ubrogepants with placebo and we do not know whether it is more effective than current standard therapies.

Apart from nausea, somnolence and dry mouth, ubrogepants appears safe. Development of gepants were terminated when trials involving earlier gepants in migraine prophylaxis were associated with liver toxicity. Ubrogepant has been used in acute migraine management and studies are required to evaluate the long-term safety of ubrogepants.

Current standard treatment for acute migraines include ergotamine, triptans and NSAIDs. There are precautions when used in patients with coronary and cerebrovascular disease. Based on the known mechanisms of action, ubrogepant may be ideal for this group of patients. However, the trials thus far have not included patients with those risk factors. Future studies will need to involve these populations.


Lipton R, Dodick D, Ailani J, et al. Effect of Ubrogepant vs Placebo on Pain and the Most Bothersome Associated Symptom in the Acute Treatment of Migraine The ACHIEVE II Randomized Clinical Trial. JAMA. 2019;322(19):1887-1898. doi:10.1001/jama.2019.16711

Dodick D, Lipton, Ailani J, et al. Ubrogepant for the Treatment of Migraine. N Engl J Med 2019;381:2230-41. DOI: 10.1056/NEJMoa1813049