Abbreviated breast MRI – how useful is it?

8th July 2020, Spectrum Radiology

Adjunct screening with dynamic contrast-enhanced (DCE)-MRI was first recommended for women at high (>20%) lifetime risk of breast cancer, facilitating earlier cancer detection and reducing interval cancers. Even in women at average risk of breast cancer, there is evidence that they might also benefit from screening MRI.

Apart from the cost of MRI equipment, other costs include the relatively long acquisition, limiting high-volume patient throughput and interpretation times involved in a full diagnostic protocol.…

Diabetic foot ulcers – out of sight, out of mind?

29th June 2020, Dr Chee L Khoo

diabetic foot

One in three patients with diabetes will develop diabetic foot ulcers (DFU). This typically occurs in the setting of peripheral artery disease, peripheral neuropathy and trauma. Foot ulcers invariably leads to lower extremity amputation (LEA) and both are associated with significant morbidity and mortality. We know that poor glycaemic control contributes to the development of DFU and LEA.…

T1D & T2D – different beginnings, same fate?

28th June 2020, Dr Chee L Khoo

In type 1 diabetes (T1D), the β-cell die rapidly from a massive immunological assault and practically all the β-cells are quickly lost and hence, there is an absolute deficiency of insulin secretion. Using auto-antibody screening, we can define T1D. Do you realise that we don’t actually have a definition for type 2 diabetes (T2D).…

Covid-19 – should the healthy public wear face mask or not?

13th June 2020, Dr Chee L Khoo

We are not talking about whether front line workers should wear a mask or not. We are talking about masks for the general public. Even as medical practitioners, we are confused. How does the average member of the public decide whether to wear masks or not? There are so many different opinions from numerous different quarters.…

Ozempic – another GLP-1 agonist coming real soon

12th June 2020, Dr Chee L Khoo

Whenever there are multiple brands of the same class of drugs on the market, one always wonder whether the new kid on the block is a “johnny-come-lately” trying to break into an already crowded market with yet another drug or it’s really a new kid with much better credentials. We already have 4 GLP-1 agonists in Australia and now a fifth one will be out real soon.…

Homocysteine & MTHFR polymorphism – are they related?

12th June 2020, Dr Chee L Khoo

Like me, you probably have come across homocysteine, methionine and MTHFR gene polymorphism from time to time and are aware of some connection between those things and cardiovascular disease but not quite sure how to connect them together. Which patient should we be checking homocysteine levels in? What about the MTHFR gene polymorphism?…

Knee Osteoarthritis – is jogging good or bad?

24th May 2020, Dr Chee L Khoo

In primary care, we are frequently preventing disease or at least we try to. Apart from lifestyle measures, we prescribe statins, anti-hypertensive, aspirin and beta-blockers to reduce cardiovascular events. What about arthritis? In patients who do not have arthritis (yet) but are at high risk of degenerative osteoarthritis, is there something we can do to reduce the patients’ risk of progressing to full blown arthritis?…

Double thalassaemia – it’s more than double trouble


22nd May 2020, Dr Chee L Khoo

Let’s imagine we have a pregnant woman who tested positive for β-thalassaemia trait (minor) on antenatal screening blood tests. If both partners carry the same thalassaemia trait, there is a 25% chance of having a baby with thalassaemia major. Thus, we are advised to screen her partner for thalassaemia as well. Say, the partner’s blood picture is normal with no microcytosis and high performance cation-exchange chromatography (HPLC) shows normal levels of HbA2 and HbF.…

Medical Imaging eReferral – completing the loop in Telehealth

21st May 2020, Spectrum Medical Imaging

As many of you are consulting from home using Telehealth due to the Covid-19 pandemic, there will be occasions when there is a need for referral for medical imaging. It can be a hassle trying to print xray forms, scan them to email or to fax them to your favourite medical imaging provider. Spectrum Medical Imaging have streamlined the whole process to make life easy for all of us.…

Covid-19 and T2D – when two pandemics meet

13th May 2020, Dr Chee L Khoo

Covid-19 have exposed the numerous risks patients with type 2 diabetes (t2D) face when the two pandemics meet head on. We have seen that patients with diabetes are over-represented in patients hospitalised with Covid-19 in Wuhan. Patients with diabetes are also affected more severely if they contracted Covid-19 especially if glycaemic control is suboptimal.…

Can flu vaccination really reduce Covid-19 infection?

11th May 2020, Dr Chee L Khoo

flu vaccination and Covid-19

Most of you would have run out of flu vaccines by now. The bad news is that we don’t know when new stocks will arrive. So much for the assurance from the government in mid-March that “there is enough vaccines for all who needs them” but “go to your GP now anyway”.…

CovidSafe App – should we install the app?


11th May 2020, Dr Chee L Khoo

Although the Covid-19 pandemic seems to be under some control, we are still in danger of a second wave if we relaxed the social distancing rules too much too quickly. One of the big unknowns is what is the proportion of people with SARS-COV-2 who are asymptomatic? These are the people we are not testing.…