MAFLD – Latest consensus statement for assessment in primary care

28th September 2024, A/Prof Chee L Khoo

MALFD

Patients are often given tacit recommendations about lifestyle changes for MAFLD because it’s “just a little fat in the liver”. For those of us who have that few patients with those liver as well as non-liver complications, we will remember how horrible these patients fare moving forward. Yet, we can’t refer all our patients with fatty liver to the hepatologist.…

Diabetic retinopathy – a new paradigm change in management coming…

28th September 2024, A/Prof Chee L Khoo

diabetic retinopathy (DR)

Diabetic retinopathy (DR) is the leading cause of new cases of blindness in patients with diabetes mellitus. In 2020, more than 103 million individuals with diabetes mellitus worldwide were affected by diabetic retinopathy and it is expected that this number will increase to 160 million by 2045 (1). We are all familiar with the association between poor glycaemic control and diabetic retinopathy development and progression.…

CKD – high protein intake or not?

12th September 2024, A/Prof Chee L Khoo

Protein

Inadequate protein intake in older adults may cause impairments of muscle mass and muscle function as well as impairment in immune function. Higher protein intake has been associated with increased muscle mass and strength, slower rate of bone loss, higher bone mineral density, lower risk of frailty, and improved cardiovascular function and recovery from illness (including wound healing) (1,2).…

Understanding radiation dose in CT scans

8th September 2024, NIA Diagnostic Imaging

CT

Computed tomography (CT) is widely recognised as the gold standard for detecting and diagnosing a broad range of pathologies due to its ability to provide detailed cross-sectional imaging. However, concerns about radiation exposure continue to be raised by both patients and clinicians. As a result, it is crucial to understand the impact of technological advancements in ensuring that radiation exposure is kept as low as reasonably achievable (ALARA) while still maintaining diagnostic accuracy.…

VLCD – does it work? Is it safe?

30th August 2024, A/Prof Chee L Khoo

Up until GLP1RAs +/- GIPs were shown to be efficacious in assisting patients lose weight and keeping the weight off, long term sustainable weight loss was practically unachievable. Not everyone wants to or is able to afford bariatric surgery to assist in weight loss. Even then, the weight loss is usually not sustainable. International guidelines (including Australian) include medical nutritional therapy in the management of obesity.…

Hypertriglyceridaemia – is fenofibrate all we have?

24th August 2024, A/Prof Chee L Khoo

Last fortnight we looked at the effects of hypertriglyceridaemia (HTG) on atherosclerosis. We explored the source and metabolism of triglycerides (TG). We saw how important lipoprotein lipase was in regulating plasma TG. Triglyceride levels are closely related to plasma triglycerides rich lipoprotein (TRL) and TRL remnants. All three components penetrate through the endothelium into the subendothelial space where atherosclerotic inflammation occur.…

Plasma glucose – how accurate is the reading?

24th August 2024, A/Prof Chee L Khoo

glucose analysis

Plasma glucose levels is such a simple test that we take for granted its reliability. The glucose level is absolutely critical in many of our clinical management. It governs whether we diagnose someone with diabetes or not and that have many regulatory implications. We have discussed the diagnosis and management of gestational diabetes mellitus (GDM) and how it affects maternal and offspring outcomes and future risks to both.…

Role of CT Enterography in Crohn’s Disease Mx

11th August 2024, NIA Diagnostic Imaging

CT enterography (CTE) plays a vital role in the management of Crohn’s disease, a chronic inflammatory bowel disease (IBD). Crohn’s disease is the most common indication for a CTE, primarily used to determine diagnosis and complications (5) to guide effective treatment, and for monitoring disease progression and response to treatment.

WHAT IS CROHN’S DISEASE?

Hypertriglyceridaemia – is it really bad?

11th August 2024, A/Prof Chee L Khoo

Hypertriglyceridaemia

Treating the CV risk factors like hypertension, diabetes mellitus, hypercholesterolemia and smoking have led to significant reductions in cardiovascular disease and mortality. However, up to 25% of first-time patients with myocardial infarction are SMuRF-less. We explored the issue last fortnight. Essentially, SMuRF-less patients are patients who do not have the usual standard modifiable risk factors (SMuRF).…

Does low salt really reduce BP and CVD?

More salt?

High salt intake is said to independently contribute to high blood pressure and ultimately, increase cardiovascular disease (CVD). There are also many other diseases that are similarly associated with high salt intake. How robust is the evidence though? As we ponder about the associations, we may or may not push the message of salt reduction as strongly as we should.…

HbA1c in early pregnancy – is it a good screening test for GDM?

25th July 2024, A/Prof Chee L Khoo

The current gold standard for screening for gestational diabetes mellitus (GDM) for women with no risk factors for hyperglycaemia is an oral glucose tolerance test (OGTT) at 24-28 weeks’ gestation. Women with risk factors are recommended to have an OGTT in the first trimester. Unfortunately, many women are nauseous during the first trimester and performing an OGTT during that time can be very unpalatable.…