Diabetes & Obesity

Prediabetes to diabetes – is prevention enough?

27th January 2026, A/Prof Chee L Khoo We are very familiar with preventing the progression of prediabetes to type 2 diabetes (T2D). Achievement of remission involves multi-component interventions including dietary and physical activity measures and often, pharmacological intervention. Patients with T2D are at heightened cardiometabolic complications. You would think that preventing the progression from prediabetes […]

Posted in Cardiology, Diabetes, Obesity & Metabolism | Tagged , , , , | Comments Off on Prediabetes to diabetes – is prevention enough?

Incretin therapy for CV benefits – here comes the agents

28th December 2025, A/Prof Chee L Khoo We discussed the Lancet Commission’s clinical obesity 12 months ago. Clinical obesity is obesity in the presence of a clinical disease (whether complication or co-morbidity). This is why the PBS is funding semaglutide for patients with obesity and established cardiovascular (CV) disease and not obesity on its own. […]

Posted in Cardiology, Diabetes, Obesity & Metabolism, GP Issues | Tagged , , , , | Comments Off on Incretin therapy for CV benefits – here comes the agents

Idiopathic intracranial hypertension – is it really idiopathic?

11th December 2025, A/Prof Chee L Khoo We all have a handful of patients witth idiopathic intracranial hypertension. It is often diagnosed by someone else incidentally. While the full pathophysiology of the condition is still not clear, we know enough about the condition to know who may be at highest risk and perhaps, diagnose the condition early to prevent visual loss. Medical […]

Posted in Diabetes, Obesity & Metabolism, Neurology | Tagged , , | Comments Off on Idiopathic intracranial hypertension – is it really idiopathic?

The changing landscape in the management of MAFLD/MASH

23rd November 2025, A/Prof Chee L Khoo Patients used to be given tacit recommendations about lifestyle changes for metabolic dysfunction associated fatty liver disease (MAFLD) because it’s “just a little fat in the liver”. For those of us who have that few patients with those liver as well as non-liver complications, we will remember how […]

Posted in Diabetes, Obesity & Metabolism, Hepatology | Tagged , , , , | Comments Off on The changing landscape in the management of MAFLD/MASH

The many clinical trials of semaglutide

11th October 2025, A/Prof Chee L Khoo Weekly semaglutide injectable has been around for some years now. Even with my special interest in diabetes and obesity, I am getting confused with all the clinical trials involving semaglutide in patients with obesity with or without diabetes. They all have very innovative acronyms most of them starting […]

Posted in Cardiology, Diabetes, Obesity & Metabolism | Tagged , , , , , | Comments Off on The many clinical trials of semaglutide

Creatine supplements – do they do anything?

22nd August 2025, A/Prof Chee L Khoo We always worry when athlete patients take supplements to improve their workout and performance. We don’t really know what these “supplements” are. We don’t really know whether they work or whether they are safe. One of the most commonly used supplements is creatine. Does it help muscle building […]

Posted in Bone & Joints, Diabetes, Obesity & Metabolism | Tagged , , , | Comments Off on Creatine supplements – do they do anything?

Oral GLP1-RAs coming soon? – they are already here

13th August 2025, A/Prof Chee L Khoo We know the ongoing cost and availability of anti-obesity medications (AOM) the likes of Wegovy and Mounjaro although we have been assured that the supply issue is behind us now. Part of the problem with cost relate to the manufacturing cost of the devices. In fact, the rate […]

Posted in Cardiology, Diabetes, Obesity & Metabolism | Tagged , , , , | Comments Off on Oral GLP1-RAs coming soon? – they are already here

HFpEF – what else can we use in addition to an SGLT2 inhibitor?

28th July 2025, A/Prof Chee L Khoo We are all aware of the four pillars of treatment in the guideline directed medical treatment (GDMT) of patients with heart failure with reduced ejection fraction (HFrEF) – SGLT2 inhibitors (SGLT2i), angiotensin receptor neprilysin inhibitor (ARNI), beta blockers and mineralocorticoid receptor antagonist (MRA). When we come to heart […]

Posted in Cardiology, Diabetes, Obesity & Metabolism | Tagged , , , , | Comments Off on HFpEF – what else can we use in addition to an SGLT2 inhibitor?

The new ADIPS recommendations for GDM – how did we get here?

30th June 2025, A/Prof Chee L Khoo You would have no doubt noticed headlines everywhere about the new criteria for GDM diagnosis that was just released a few days ago. Why is there such a buzz? Why is everyone seemingly that excited? We have covered many of the issues covered by ADIPS over the years […]

Posted in Diabetes, Obesity & Metabolism, GP Issues, Women's Health | Tagged , , , , | Comments Off on The new ADIPS recommendations for GDM – how did we get here?

Who should not go vegan?

30th June 2025, A/Prof Chee L Khoo There are many reasons why some of our patients go vegetarian. A primarily plant-based diet with less meat is supposed to lower the morbidity of chronic diseases, including cardiovascular diseases, type 2 diabetes, and certain cancers [1]. Some patients may choose to reduce their food-related ecological footprint. A […]

Posted in Diabetes, Obesity & Metabolism, GP Issues | Tagged , , , | Comments Off on Who should not go vegan?

Type 5 diabetes mellitus – where did that come from?

27th May 2025, A/Prof Chee L Khoo We know about type 1 to type 3 diabetes mellitus. I didn’t know that there was a type 4 and now they tell us there is a type 5. For someone who has a special interest in things diabetes, this is definitely news to me. Actually, on further […]

Posted in Diabetes, Obesity & Metabolism | Tagged , | Comments Off on Type 5 diabetes mellitus – where did that come from?

Reducing LDL-C for brain health – how low do we need to go?

27th April 2025, A/Prof Chee L Khoo We recently looked at the LDL-C levels needed to stabilise plaque progression and the LDL-C levels needed to cause plaque regression. Plaque stabilisation and regression leads to reduction in cardiovascular events. Dyslipidaemia (especially LDL-C) is also associated with cognitive impairment and dementia and reducing those numbers with statin […]

Posted in Cardiology, Diabetes, Obesity & Metabolism, Internal Medicine | Tagged , , | Comments Off on Reducing LDL-C for brain health – how low do we need to go?