Diabetes & Obesity

24th April 2026, A/Prof Chee L Khoo Australian and international guidelines recommend 150– 300 min of moderate physical activity (MPA), 75–150 min of vigorous physical activity (VPA), or a combination of both per week (1,2). Some people prefer slower but longer exercises while other prefer more intense for shorter periods of time. There is data […]

29th March 2026, A/Prof Chee L Khoo Just as we are getting used to the GLP1-RA and the bi-hormonal GLP1/GIP co-agonists in the management of type 2 diabetes (T2D) and obesity, the playground is about to get more crowded. Retatrutide is a once weekly triple hormone receptor agonist. It is a single molecule that can […]

28th March 2026, A/Prof Chee L Khoo Not all women with gestational diabetes mellitus (GDM) are the same. There are three subtypes of GDM – isolated fasting hyperglycaemia, isolated post prandial hyperglycaemia or combination of both being abnormal. Similarly, not all women with GDM end up the same after delivery. Women with GDM are recommended […]

13th March 2026, A/Prof Chee L Khoo Diabetic complications are categorised as either microvascular or macrovascular. Microvascular complications are typically associated with suboptimal glycaemic control which damages the small capillaries that supply our retina, myocardium, kidneys and feet including the long nerves. The brain, in particular, is susceptible to damage by both big and small […]

24th February 2026, A/Prof Chee L Khoo We know that suboptimal glucose control is very associated with the incidence and progression of diabetic retinopathy. The duration of diabetes, high systolic BP, smoking, lack of exercise, poor diet and depression are the other risk factors which increase the incidence of diabetic retinopathy as well as the […]

24th February 2026, A/Prof Chee L Khoo People on shift work are at higher risk of cardio-metabolic dysfunction including cardiovascular (CV) diseases. People on rotating day and night shifts are even worse because their body has to adapt to a new time clock every couple of weeks. These people include ambulance officers, police officers and […]

12th February 2026, A/Prof Chee L Khoo When we think about major complications in patients with type 2 diabetes (T2D), we automatically think of an atherosclerotic cardiovascular event. While diabetic kidney disease, diabetic foot disease and retinopathy makes the quality of life miserable the last 5-7 years of their shortened lifespan but it is ASCVD […]

27th January 2026, A/Prof Chee L Khoo We are very familiar with preventing the progression of prediabetes to type 2 diabetes (T2D). Achievement of remission involves multi-component interventions including dietary and physical activity measures and often, pharmacological intervention. Patients with T2D are at heightened cardiometabolic complications. You would think that preventing the progression from prediabetes […]

28th December 2025, A/Prof Chee L Khoo We discussed the Lancet Commission’s clinical obesity 12 months ago. Clinical obesity is obesity in the presence of a clinical disease (whether complication or co-morbidity). This is why the PBS is funding semaglutide for patients with obesity and established cardiovascular (CV) disease and not obesity on its own. […]

11th December 2025, A/Prof Chee L Khoo We all have a handful of patients witth idiopathic intracranial hypertension. It is often diagnosed by someone else incidentally. While the full pathophysiology of the condition is still not clear, we know enough about the condition to know who may be at highest risk and perhaps, diagnose the condition early to prevent visual loss. Medical […]

23rd November 2025, A/Prof Chee L Khoo Patients used to be given tacit recommendations about lifestyle changes for metabolic dysfunction associated fatty liver disease (MAFLD) because it’s “just a little fat in the liver”. For those of us who have that few patients with those liver as well as non-liver complications, we will remember how […]